Isaacs, who was 59 years old, died on Monday morning at his home in London where he spent part of his time.
He leaves behind a wife and children.
Close friends told BBC Caribbean that he had originally been diagnosed with cancer of the liver which had then spread.
The Jamaican reggae singer, who was nicknamed the Cool Ruler, was best known for the song 'Night Nurse'.
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R.I.P Mr. Isaacs! Real Legend!
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