The Argentina ace has yet to make his debut for the Blues but he has played a big part during pre-season.
And boss Phil Scolari appears to have given the youngster a huge chance by handing him the number.
Di Santo, 19, takes over the shirt from Steve Sidwell, who moved to Aston Villa this summer.
New signings Deco and Jose Bosingwa have taken the No20 and No17 shirts respectively.
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